终止知情同意之后，所有临床研究相关的操作均需要结束。如果患者仅仅是终止治疗，之后的随访，如方案要求的随访、SAE随访，等，应该在知情同意书中明确说明，征询受试者同意后方可收集。可以参考的法规是：

• FDA Informed Consent Information Sheet, Guidance for IRBs, Clinical Investigators, and Sponsors

• FDA 21 CFR 213.62 (b) & 812.40(a)

• FDA Guidance for sponsors, clinical investigators, and IRBs--data retention when subjects withdraw from FDA-regulated clinical trials: Oct 2008