Answer： Clinical research coordinator (CRC) role is to assist investigator to conduct clinical trials at the site. ICH GCP E6 4.2.3 states that “The investigator should have available an adequate number qualified staff and adequate facilities for the foreseen duration of the trial to conduct the trial properly and safely. It is advisable to have a contract between an investigator site and a CRC company only. The contract should clearly describe each party’s roles and tasks. It is ultimately the investigator’s responsibility. A contract is a legal document and the agreement between parties.